Contribute to missioncommand/emp3-web development by creating an account on GitHub. Prognosis. Watch Video that becomes popular through the process of Internet sharing, typically through video sharing websites, social media, whatsapp or email. General description. Browse Monoclonal Anti-EMP3 antibody produced in mouse and related products at MilliporeSigma. Committed to processing timely and accurate performance evaluations to ensure appropriate advancement and assignment opportunities. Description. View Rabbit Polyclonal anti-EMP3 Antibody (NBP3-17247). 0K-DILAK-M REGRET ANPIL (OFFICIAL VIDEO) 14. Free Download Secure Download. 1 version to enhance web performance and efficiency. 5/5. It is expressed as a 20‑25 kDa molecule depending on the degree of glycosylation. 00. #1 · Jul 24, 2022. 级别: 警告等级1. Its dysregulation is associated with glioma and neuroblastoma. com. Sunnery James, Ryan Marciano. Electron Microprobe. Cisplatin (CDDP)-based chemotherapy is a standard treatment for gastric cancer (GC). Stream, listen and download “Nasty C – Kill The Noise ft Anica & Maglera Doe Boy” 320kbps mp3 Descarger torrent datafilehost fakaza zippyshare toxicwap. There is a huge range of resolutions available. Myfreemp3 plays and indexes MP3 files from various sources on the Internet. Furthermore, EMP3 suppressed T cell infiltration into GBM. CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. ago. Eat Spin Rave Drop - Red Hot New EDM 2013. Download scientific diagram | EMP3 is highly expressed in tissue sections from HCC patients and in HCC cell lines. ago. Remember you can always share any sound with your friends on social. ago. However, the exact trafficking role of EMP3 and how it promotes oncogenic signaling in GBM remain unclear. 69 posts · Joined 2021. It is similar to the original EMP 3-inch that I reviewed a few years back, but is priced a little lower, is lighter and smaller, has fiber optic but not tritium sights, and has some. 1. The 5' region of the EMP3 gene revealed a typical CpG island on the start site of the transcripton. If you are changing the thickness of grips from what you now. Emp3h. If he jumps up in spite of the warning, bump his nose once with the palm of your hand. js is installed navigate to the root of the EMP3 project, open a command prompt and run: raw. Python - Filter dictionary values in heterogeneous dictionary. The diagnosis of glioblastoma (GBM) is applied to highly aggressive primary central nervous system (CNS) tumors. 29. Epithelial membrane protein 3 (EMP3) is a multipass transmembrane protein in the peripheral myelin protein 22 family. We use cookies to provide you with a great experience and to help our website run effectively. Its molecular basis is unknown. Designed specifically for the 9mm cartridge, the EMP features shorter dimensions making it one of the smallest 1911s out there. Premium Feel The Energy (Sunrise Festival 2013 Anthem) Skytech, Fafaq, Alex. Our Custom 1911 pistolsmiths have over 200 combined years of experience and individually hand fit every major component of your firearm. A list of available songs will appear. Yes. 2021 Oct 7;18378. ぴすぴす ︎('ω' ︎ )「私、漫画の原作者になる!」 『ノベルコミック”エルミリ!盟主は手綱を握りたい“』を執筆連載中👀 小説家になろう・ノベプラ 📣応援職人 ️ 応援は応援返しが最優先🙌🏻引用とRTで召喚してください TLは基本見てない😑🌸FFという概念にあまりこだわりがない. Album Downloads. We'd love to hear about your overall impressions of our site, as well as any recommendations for how we could make it better. 2. Introduction. P?륝hannel Logic Level Enhancement Mode Field Effect Transistor, EMB03P03H DatasheetDOWNLOAD AUDIO. Discover, buy and download high quality tunes for reasonable prices!Search and download free mp3 music files at 320kbps audio quality. EMP3 interacts with the P2X7 purinergic receptor on monocytes. This review addresses the structural and func. emp3z. 2 (Wang et al. Sci. Developers can show information here about how their app collects and uses your data. Epithelial membrane proteins (EMPs) have been reported in various malignant tumors but their expression in PTs is unclear. Int. Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). In fact, the total size of Emp3z. We'd love to hear about your overall impressions of our site, as well as any recommendations for how we could make it better. However, the exact trafficking role of EMP3 and how it promotes oncogenic signaling in GBM. EMP3 & Bendji Allonce), Boosie Badazz (feat. Personal websites (such as blogs, portfolios, etc) do not need HTTPS connection. Mp3juices allows you to download music for free. I didn't read. In this category you have all sound effects, voices and sound clips to play, download and. However, chemoresistance is a major obstacle for CDDP application. We found that EMP3 was hypermethylated 36. Find more sounds like the One Direction 18 (Audio) [eMP3h one in the music category page. Blondedy Ferdinand_Dperfect - Podyab Yo (Official Music Video) [eMP3h. M5930. Elevated EMP3 in GBM areas was accompanied by high expression of PD-L1 and abundant M2 TAM recruitment but a lake of T cell infiltration. 2. It includes four closely related members ( PMP22, EMP1, EMP2 and EMP3), as well as the additional and more distant member MP20. Vanessa Désiré Feat. And in order to download music that captured, you do not need to go through a tedious registration process. HR: Which employees earn more than the average salary for their department? (correlated) 4. MP3Juice is the most popular free search engine tool to download free songs or music in a second. J. 7 kB which makes up the majority of the site volume. In malignant PTs, the epithelial component showed decreased expression of EMP1 ( P = 0. Aberrant expression of epithelial membrane protein-3 (EMP3) was reported in different kinds of cancers. In total, 185 PTs were included in this study, and comprised 138 benign, 32 borderline, and 15 malignant PTs. 9762: 42: ENTPD4: Ectonucleoside triphosphate diphosphohydrolase 4Monoclonal Anti-EMP3 antibody produced in mouse. In the pre. upvote for pointing out that Atwood's song choice is a pretty significant problem with this test - buzzing electronic rock music from a song recorded in 1985 is unlikely to show much of difference in encoding quality - the song doesn't really explore dynamic range, the vocals are highly processed with reverb and such in the original recording, and harmonic distortion. 3 for several solid tumors, including tumors of the nervous systems. The primer mix has been tested to generate satisfactory qPCR data on ABI 7900HT by using the following PCR program: Stage 1: Activation: 50 °C for 2 min; Stage 2: pre-soak:95 °C for 10 min; Stage 3: Denaturation: 95 °C. Bali Cinematic Stock Footage mp3. @EmP3h 余談 土日にかけて、仕事の方のアカウントがプチバスしてたっぽいんですけど、そこまで頻度は高くないけどプチバズぐらいなら仕掛けるのは得意なんだな〜と再確認しました 😂 前の新聞診断のやつの自分の結果を思い出して笑ってます笑漫画ってたぶん絵ありきだからセリフが薄いんだろうけど、RTのやつも含め文字で理解できるように作られてれば全然平気. You can also save your music to your device. We understand that downloading mp3 from YouTube and Spotify can be tricky and very slow, so. The NIC EMP-3 Mercury Monitor is designed for measuring gaseous mercury in work environments. com supports HTTP/2. Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). The patented EMP design stands apart in the 1911 market, having been specifically engineered around the 9mm cartridge. Blxckie & 25K – Ntoni Na. EMP3 overexpression is associated with oligodendroglial tumors. Lee Mech. Doctor Strange in the Multiverse of Madness. Go to mp3juices on your web browser. 1). With us you’ll find the latest clothing for spring, summer, autumn and winter, that will perfectly accentuate your personality. Find the latest lyrics Amapiano Fakaza Datafilehost, Tubidy, JuicePaw 2023 and Zippyshare. SoundCloud. Anti-SARS-CoV-1/2 NP Antibody, clone 1C7C7 ZooMAb ® Mouse Monoclonalspringfield emp 3". However, its effects on tumor suppression are. • 2 yr. Galloway Precision Bench Block. This free program is an intellectual property of Field Precision. I often use the EMP and DEPT tables for test and demonstration purposes. Mp3Juice offers a variety of file formats, including MP3, MP4, and M4a. Top songs chart list across all genres, ranked by Apple Music, The most popular hit music and trending songs. 3. The EPM3 is a semi-automatic weapon that uses a miniature fusion reactor to generate and fire hardened bolts of condensed energy at range; under prolonged fire, the. So with this code, I am now getting the correct answer of this: Employee 1: Name: Susan Meyers ID number: 47899 Department: Accounting Title: Vice President Employee 2: Name: Mark Jones ID number: 39119 Department: IT Title: Programmer Employee 3: Name: Joy Rogers ID number: 81774 Title: Programmer Process finished with exit code. Epithelial membrane protein 3 (EMP3) is an N-glycosylated tetraspanin with a putative trafficking function. This is the time to be happy for all the music lovers as I am listing out great free mp3 music download sites. Sigma-Aldrich. I looked into, pretty hard, the original EMP way back when. The MAM blood group system (International Society of Blood Transfusion [ISBT] 041) consists of one high-prevalence antigen to date, first detected in a 31-year-old woman during her third pregnancy. Run the loop for n/2 times where ‘n’ is the number of elements in the arraylist. However the weight and caliber make it soft-shooting and fun at the range. 25% of websites need less resources to load. Nonetheless, the biological fun. Play and Download your favorite old, new, latest & rare mp3 songs, full music albums or a music artisListen to music by Emp3 on Apple Music. Experimental findings based on glioma and non-glioma models have demonstrated the. EPM-3: EVALUATIONS . By using this website, you agree to our use of cookies. [8] The protein is characterized by 4 transmembrane domains and. EMP3 was associated with immunosuppression in GBM. Introduction. According to statistics, the global. , 2017a). 3 in the Homo sapiens chromosome. Best in class range. View Mouse Monoclonal anti-EMP3 Antibody (439949) [Allophycocyanin] (FAB4505A). Tau specificity score (RNA)i. Download Kamo_ww – Chommie ft Chley Mp3. Evidence at protein level. The GAS3/PMP22 family members play roles in cell migration, growth, and differentiation. Evidence at transcript level. , 1995). HR: Who works in James Marlow's department? 2. Epithelial Membrane Protein 3 (EMP3), a 4-transmembrane glycoprotein, first gained attention as a putative tumor suppressor. Committed to processing timely and accurate performance evaluations to ensure appropriate advancement and assignment opportunities. They are all my favorite music downloaders, so you can use them with confidence. Other mp3 sites etc have things nearly. Among the. Springfield Ronin EMP 9-Round SS magazines -9MM. Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. (YTMP3. Homo sapiens (Human) Amino acids. MP3 Juice is a music and free mp3 download search engine. The EMP3. ago. 1. The purpose of this study is to investigate the expression of the epithelial membrane proteins (EMP) 1, 2, and 3 in adrenal gland neoplasm and to explore the broader implications of this. The music library and types of songs available are very large and extensive. HTTP/2 (Hypertext Transfer Protocol version 2) is a major revision of the HTTP protocol, which is the foundation of data communication on the World Wide Web. Seller: Elk County Ammo and Arms. goldify. Development of HCC is a multistep process, in which the chronic infections of hepatitis. 5S Electret Microphone Power Adapter - Ambient Recording 1 Year Warranty Features: 3. MP3Juices allows you to search for and download music in up to 320 kbps quality to your local device. A low level of EMP1 transcript was detected in oral,. However, the specific function and regulatory mechanism of EMP3 in primary breast carcinoma remain to be elucidated. 26: 2: ODAD1: Outer Dynein Arm Docking Complex Subunit 1fragments. EMP3 is a protein composed of a 163-amino acid sequence, which is expressed from its gene located on the band of the 19q13. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive. com is SAFE to browse. Its interface is simple and well organized. It is expressed as a 20‑25 kDa molecule depending on the degree of glycosylation. In oligodendroglial tumors, it was strongly associated with both IDH1/IDH2 mutations and total 1p/19q codeletion and inversely with EGFR gene amplification. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Related Posts: Kamo_ww, Nvcho, XDUPPY, QuayR Musiq - Abafana; Ezase Thupa & MARC ft Busta 929, KNOWLEY-D, 20ty… ALBUM: DJ Jaivane - 5th Annual J1MS“#子育てしてる人にだけ分かるホラー話 一昨日片付けたばかり”For the Mouse gene set with the same name, see HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION. 2 kB. Just use it to convert YouTube videos longer than 2. In silico analysis showed that epithelial membrane protein 3 (EMP3) is associated with favorable survival, and negatively regulates cell cycle S-phase. 3 [] [] []. Guess I gotta stop complaining. Free Mp3 Cloud: find, listen and download Mp3 of your favorite songs. Epithelial membrane protein 3 (EMP3) belongs to the peripheral myelin protein 22-kDa (PMP22) gene family of small hydrophobic membrane glycoproteins, which include four closely associated members; PMP22, EMP1, EMP2 and EMP3, in additional to the more distant member, MP20 (1,2). This time around we discuss the SA Ronin EMP 3″, a packable, three-inch barrel 1911-style pistol. Teams. Plops__. Epithelial membrane protein-3 (EMP3), a typical member of the epithelial membrane protein (EMP) family, is epigenetically silenced in some cancer types, and has been proposed to be a tumor suppressor gene. MSRP $917 - $1,313. Feel free to share or request a site. 45 ACP. Experimental findings based on glioma and non-glioma models have demonstrated the. pCloud is one of the best places to upload your music collection because of its music playback features, sharing capabilities, and reasonable free storage of up to 20 GB. com. exe is the most common filename for this program's installer. Emp3-overexpressing RAW264. 2. There is various way to create an object in Java that we will discuss in this section, and also learn how to create an object in Java. 🔴 On the MY FREE MP3 music download portal users will find new music songs to their liking genres - Rock and soul, Pop, Latin, Jazz, Hip hop, Folk, Electronic, Country, Blues, Asian, African and a lot of Remixes. The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven members: PMP22, EMP1, EMP2, EMP3, PERP, brain cell membrane protein 1, and MP20. 威望: -1. Seoul Vibe. EMP3 is expressed as a 20 - 25 kDa molecule depending on the degree of glycosylation. Lemp3. com] 11. Enhanced DNA damage repair capacity attenuates cell killing of DNA-damaging chemotherapeutic agents. Validated Applications: Flow. The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven members: PMP22, EMP1, EMP2, EMP3, PERP, brain cell membrane protein 1, and MP20. 1. Click for more info. • 2 yr. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Well, it certainly is small, looks great, and appears to have a lot of features. Find top songs and albums by Emp3 including Kiss me again (feat. It includes four closely related members ( PMP22, EMP1, EMP2 and EMP3), as well as the additional and more distant member MP20. 3. EMP1 expression in vivo shows a complex pattern of cell type-specific difference. EMP3 could induce macrophage polarization. Here, the authors show, by combining multiple single-cell approaches. 6K subscribers in the RequestASite community. A fully fledged and versatile multiplayer with support for all modern audio & video formats. 40 S&W. The EMP3 promoter hypermethylation has been found in 39. 3–1. Epithelial membrane proteins (EMPs) have been reported in various malignant tumors but their expression in PTs is unclear. It is composed of approximately 160 amino acids, forming two extracellular domains, a small cytoplasmic. Histologically, GBM is characterized by diffusely infiltrating tumor cells with nuclear atypia, high mitotic index, microvascular proliferation, and/or necrosis [1,2]. While the EMP 3 doesn’t break any capacity records, it has upped the amount of bad guy stoppers you can carry to 10 (9+1) in a small, concealable package. Welcome to Mp3hunters - a popular and free mp3 search engine and tool. Smith Syst. The Springfield Armory EMP 3” 9mm is a single-action-only semi-automatic pistol. 25K 2023 Songs. doi: 10. EMP3 lies within Education Tools, more precisely Science Tools. , 1995). Music may be found all over the internet, including the most popular music streaming and mp3 download services. EMP3. 5 mg/mL). We identify EMP3 as its encoding gene, establishing MAM as a new blood group system, and. 163 (go to sequence) Protein existence. The protein contains four transmembrane domains and two N-linked glycosylation sites. In silico analysis showed that epithelial membrane protein 3 (EMP3) is associated with favorable survival, and negatively regulates cell cycle S-phase. If you have any remarks, please fill out the form below or send an email to emp3wala@gmail. emp3h. Anal. Let yourself be entranced by the enchanting music and immerse yourself in the mesmerizing world of. It takes a tremendous amount of effort. The epithelial membrane protein 3 ( EMP3) is a candidate tumor suppressor gene in the critical region 19q13. Methods: The data from CGGA and TCGA database were used to analyze the expression of EMP3 and its correlation with clinical. Mp3 Juice also known as Mp3 Juice cc, MP3Juice cc, MP3Juice, MP3Juices, Mp3 Juices, and Mp3 Juice are the top sites to get MP3 downloaders for free. MP3Juices allows you to search for and download music in up to 320 kbps quality to your local device. 保志見祐花 *婚前なれそめファンタジー*仮面装備の冷酷盟主は、光の溺愛男に進化する*We’re unlocking community knowledge in a new way. The results showed that the expression level of EMP3 was. @EmP3h Feb 27 いずれ100になるかもしれない話 突き抜けてしまうかもしれない話 文だけどコミックのように読める話 キャラが動き出す話 カテゴリエラーで行き場がないから 荒野を突っ走っている話 青田買いしてみませんかーーーーー ‼️ ノベルコ. 14670/HH-18-378. 5% of all breast tumors. MediaHuman works great for me, but is unfortunately not Open Source (so you have to see for your self if you want to trust this program). I vowed I would never be a 1911 guy. “Chommie” leaves nothing to desire. Establishment of a nomogram with EMP3 for predicting clinical outcomes in patients with glioma: A bi-center study. Useful information about the gene from Entrez. It could be limp wrist with EMP4, and I tightening. A range of models is available with standard sockets to fit the plugs of most popular wireless systems in 2 or 3-wired configuration. Feel free to share or request a site. 50 USD. It belongs to the peripheral myelin protein 22-kDa (PMP22) gene family based on the sequence and structural homology [] []. Free shipping. Python program to update a dictionary with the values from a dictionary list. To examine the relationship in human UC cells parental TCC-SUP bladder cancer cells, which express a low level of exogenous rat p185 neu, and TCC-SUP-N5 cells, which express a high level of exogenous rat p185 neu, were chosen for in vitro experiments. It includes four closely related members ( PMP22, EMP1, EMP2 and EMP3), as well as the additional and more distant member MP20. Python List: Exercise - 63 with Solution. 1, 2, 3 Regardless of tumor malignancy and aggressive treatment, the average median OS time is still only 12–18 months. Enhanced DNA damage repair capacity attenuates cell killing of DNA-damaging chemotherapeutic agents. It is a safe and completely free online MP3 streaming media player. 3 for several solid tumors, including tumors of the nervous systems. Once Node. EMP3: Products. PubChem. Bank 8 v4 (October 2009) (Sample) 2. Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Mol. There are lots of genres with lots of artists from various years available there; this makes. 3 in the Homo sapiens chromosome. Just follow these steps to get your favorite songs: Open your web browser and go to MP3 Juice. Mp3juice is a worldwide downloading utility that supports 32 different languages and can be utilized by people all around the world. 3–5 However, the mechanisms underlying metastasis are quite complex and are far from been fully understood. apparently the EMP dovetail is 60° and normal 1911 dovetails are 65°. Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract and the sixth most common gastrointestinal cancers [1, 2]. 163 (go to sequence) Protein existence. But WOW, even though the EMP3 is not a full size 1911, still WOW, the best shooter out of my family, by far, no question. Bank 7 v10 (October 2009) (Sample) 3. Soulseek is the best way to download music. Validated Applications: CyTOF-ready, Flow. We found that EMP3 was a potent protein in M2 TAM polarization and recruitment that impaired the ability of GBM cells to secrete CCL2 and TGF-β1. Wire Room. In an attempt to address this issue, we. TaqMan Real-Time PCR Assays. The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. In-game description The EPM3 is a heavy directed energy weapon in Call of Duty: Advanced Warfare. Its dysregulation is associated with glioma and neuroblastoma. Blood group antigens are carried by functional proteins, glycoproteins and glycolipids at the. Validated Species: Human. Mp3 Juice helps you download MP3 music without having to worry about bandages and viruses. Systematic name. empCount is not yet defined at the class level yet and you are trying to access it. EPM-3: EVALUATIONS . Anal. Springfield 1911 Ronin EMP 9mm 3" Blued / Satin Aluminum 9 Rds PX9123L. The test principle applied in this kit is Sandwich enzyme immunoassay. com is 5 years 2 months old. The biological function of EMP3 remains largely unclear. Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). We know that you, just like us, are often on the go with your mp3 player or phone and always want to have your music with. It prevailed in low-grade tumors, especially in gliomas with an oligodendroglial component, and in sGBMs upon pGBMs. Music may. Download scientific diagram | EMP3 regulates TGF-β/Smad responsive gene expression in GBM cell lines. Contact tech support. Dịch vụ nhạc số với hàng triệu bài hát và MV có bản quyền chất lượng cao, giúp bạn nghe nhạc, tải nhạc, upload và đồng bộ kho nhạc của tôi trên nhiều thiết bị. — 2. Here, the authors show, by combining multiple single-cell approaches. Our study aimed to explore the elusive functional roles and the und. Open the Mp3juice website. Find the EMP3 antibody that fits your needs. 5% of gliomas. EMP3 by Graham Getty, released 01 December 2009 1. Mp3Caprice offers a big variety of mp3 music in different styles and genres. Free shipping. The 2. The amino acid sequence homology with PMP22, EMP1, EMP2. View Mouse Monoclonal anti-EMP3 Antibody (439949) [Alexa Fluor® 488] (IC4505G). We hope you enjoy using MP3Skull for all your music needs. Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of cancer mortality worldwide, particularly in Southeast Asia including China, Taiwan, Korea and Japan, and sub-Saharan Africa [1, 2]. The latest music with high sound quality - the best mp3 downloader. A Boogie wit da Hoodie), which are available on Waploaded. Yet I can never find music on it unless it's weeks months or years old. Acknowledgement I would like to express my special thanks of gratitude to my teacher Mr. 4, 5 Although various therapeutic modalities are. 5/5. INTRODUCTION. It is highly expressed in isocitrate dehydrogenase-wild-type glioblastoma (IDH-wt GBM), and its high expression correlates with poor survival. This gene is located on human chromosome 19q13. Free Download Secure Download. Keywords: full album, artists, youtube converter, convert mp3, MP3, download, play, free MP3Juice is a free platform for searching MP3 audio files from YouTube and other platforms. Mission . In this category you have all sound effects, voices and sound clips to play, download and share. Date: April 20, 2013 Author: Nick Buytaert. In most cases, this would be the latest version (32/64-bit) from the appropriate company. Zamob – Mp3 Download Free Music, Videos, Games, and Wallpaper at zamobs. However it is usually not advised to share variables across instances this way rather advised to find a. -. . Although surgical removal is a curative treatment, systemic chemotherapy is an optimal therapeutic strategy for GC patients who are diagnosed at an advanced stage and consequently. MediaHuman works great for me, but is unfortunately not Open Source (so you have to see for your self if you want to trust this program). No Registration Required. That frame’s also remarkably slim.